We Know: All About Platelets

What are platelets?

Platelets are blood cells that are disc-shaped with sticky surfaces. They are found in blood and play a role in blood clotting. A platelet contains a granular center and protoplasm with no nucleus. Platelets are also known in medical circles as thrombocytes.

Where are platelets produced?

Platelets are produced in the bone marrow and stored in the spleen.

What is the function of a platelet?

Platelets play an important role in blood clotting. When an injury to a blood vessel is detected, platelets are the first cells that jump into action. They migrate to the location of the injured blood vessel. Their sticky surfaces provide a place for fibrin molecules to attach and to eventually form the clot.

Platelets are also important in the following capacities:

  • Store and transport chemicals
  • Engulf foreign bodies
  • Activate factors involved in the blood clotting process

How many platelets does the human body normally have?

A normal platelet count is between 150,000 to 450,000 platelets per millimeter cubed.

How are platelets measured in blood?

A platelet count test measures the amount of platelets in the blood. A blood sample is taken from a vein on the inside of the elbow for the test.

Because various conditions can affect the number of platelets in the blood, a platelet count test is used to indicate the presence of a disease or to determine whether there is excessive bleeding.

A platelet aggregation test measures the ability of platelets to form clots. This test is usually given to determine whether in inability to clot is due to bleeding issues (like hemophiliacs) or if it is the result of an acquired condition.

What causes abnormal platelets counts?

An abnormal platelet could be attributed to the presence of a pre-existing condition or excessive bleeding. Conditions that could lead to a low platelet count include:

  • Cancer chemotherapy
  • Disseminated intravascular coagulation
  • Hemolytic anemia
  • Hypersplenism
  • Leukemia
  • Massive blood transfusions
  • Idiopathic thrombocytopenic purpura

Conditions that could lead to a high platelet count include:

  • Post splenectomy syndrome
  • Primary thrombocytosis
  • Malignant diseases
  • Early CML
  • Anemia



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