We Know: All About Acetaminophen

How does acetaminophen work?

Acetaminophen acts in both an analgesic (pain reliever) and an antipyretic (fever reducer) capacity. It alleviates pain by increasing the body's threshold for pain. Acetaminophen reduces fevers by telling the brain's temperature regulating center to lower the temperature. Acetaminophen does not act as an anti-inflammatory, and it irritates the stomach less than aspirin, but works just as effectively. The FDA approved consumer use of the drug in 1951.

How does one use acetaminophen?

Acetaminophen may be purchased over-the-counter or by prescription. Acetaminophen is made in the form of tablets, capsules, liquid drops, or granules to be mixed with liquid for oral consumption. It is also available rectally as a suppository.

In what dosages should acetaminophen be taken?

Adults should take between 325 - 650 milligrams every 4 to 6 hours as directed. Children's dosage levels vary according to age. Check with your medical professional for the correct dosages.


Acetaminophen should be taken for no more than 10 days. Persons using acetaminophen to reduce fever should take the drug for no more than three days. If symptoms persist, get medical attention.

What precautions should one take when using acetaminophen?

Acetaminophen is safe for most people. However, individuals with the following conditions should seek medical advice before taking the drug:

  • Allergies
  • Simultaneously taking other prescription medication
  • Pregnancy
  • Individual has a history of liver disease and alcoholism
  • Individual drinks more than three alcoholic beverages per day

What are the side effects of taking acetaminophen?

Side effects of acetaminophen include an upset stomach and/or skin rash.

What happens when an overdose occurs?

Overdosing on acetaminophen can lead to liver damage, or hepatitis. Call the poison control center immediately, or call 911 if an overdose is suspected.

What are the common brand names of acetaminophen?

The brand names that manufacturers use to market acetaminophen include:

  • Tylenol
  • Excedrin aspirin-free
  • Anacin
  • Midol
  • Sinutab
  • Benadryl Severe Allergy and Sinus
  • St. Joseph's Cold Tabs for Kids
  • Vicodin


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